Back Cover: CH Activation Generates Period‐Shortening Molecules That Target Cryptochrome in the Mammalian Circadian Clock (Angew. Chem. Int. Ed. 24/2015). Issue 24 (8th June 2015)

• Record Type: Journal Article
• Authors: Oshima, Tsuyoshi; Yamanaka, Iori; Kumar, Anupriya; Yamaguchi, Junichiro; Nishiwaki‐Ohkawa, Taeko; Muto, Kei; Kawamura, Rika; Hirota, Tsuyoshi; Yagita, Kazuhiro; Irle, Stephan; Kay, Steve A.; Yoshimura, Takashi; Itami, Kenichiro
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 24(2015)
• Page Start: 7200
• Page End: 7200
• Publication Date: 2015-06-08
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201504172
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>A focused library of KL001 derivatives, a period‐lengthening modulator of the mammalian circadian clock, was rapidly constructed by CH activation chemistry. In their Communication on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 7193 ff., </ext-link> S. Irle, T. Yoshimura, K. Itami et al. describe both new period‐lengthening molecules and the first period‐shortening molecules that target the cryptochrome. The picture (Haruko Hirukawa) illustrates the power of the CH activation catalyst in triggering opposite modes of action in small molecules.<graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgjqk2hf9s" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>