Laboratory Alcohol Self‐Administration Experiments Do Not Increase Subsequent Real‐Life Drinking in Young Adult Social Drinkers. (23rd April 2015)

• Record Type: Journal Article
• Authors: Sommer, Christian; Seipt, Christian; Spreer, Maik; Blümke, Toni; Markovic, Alexandra; Jünger, Elisabeth; Plawecki, Martin H.; Zimmermann, Ulrich S.
• Is Part Of: Alcoholism. Volume 39:Number 6(2015:Jun.)
• Page Start: 1057
• Page End: 1063
• Publication Date: 2015-04-23
• Subjects: Alcoholism -- Periodicals; Alcoholism -- Periodicals; Alcoolisme; Electronic journals; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.861005
• DOI: 10.1111/acer.12716
• Languages: English
• ISSNs: 0145-6008

Abstract

<abstract abstract-type="main" id="acer12716-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="acer12716-sec-0001" sec-type="section"> <title>Background</title> <p>While the utility of experimental free‐access alcohol self‐administration paradigms is well established, little data exist addressing the question of whether study participation influences subsequent natural alcohol consumption. We here present drinking reports of young adults before and after participation in intravenous alcohol self‐administration studies.</p> </sec> <sec id="acer12716-sec-0002" sec-type="section"> <title>Methods</title> <p>Timeline Follow‐back drinking reports for the 6 weeks immediately preceding the first, and the 6 weeks after the last experimental alcohol challenge were examined from subjects completing 1 of 2 similar alcohol self‐administration paradigms. In study 1, 18 social drinkers (9 females, mean age 24.1 years) participated in 3 alcohol self‐infusion sessions up to a maximum blood alcohol concentration (BAC) of 160 mg%. Study 2 involved 60 participants (30 females, mean age 18.3 years) of the Dresden Longitudinal Study on Alcohol Use in Young Adults (D‐LAYA), who participated in 2 sessions of alcohol self‐infusion up to a maximum BAC of 120 mg%, and a nonexposed age‐matched control group of 42 (28 females, mean age 18.4 years) subjects.</p> </sec> <sec id="acer12716-sec-0003" sec-type="section"> <title>Results</title> <p>In study 1, participants reported (3.7%) fewer heavy drinking days as well as a decrease of 2.5 drinks per drinking day after study participation compared to prestudy levels (<italic>p</italic> < 0.05, respectively). In study 2, alcohol‐exposed participants reported 7.1% and non‐alcohol‐exposed controls 6.5% fewer drinking days at poststudy measurement (<italic>p</italic> < 0.001), while percent heavy drinking days and drinks per drinking day did not differ.</p> </sec> <sec id="acer12716-sec-0004" sec-type="section"> <title>Conclusions</title> <p>These data suggest that participation in intravenous alcohol self‐administration experiments does not increase subsequent real‐life drinking of young adults.</p> </sec> </abstract>