Severe Vitamin D Deficiency May be an Additional Cofactor for the Occurrence of Alcoholic Steatohepatitis. (2nd May 2015)

• Record Type: Journal Article
• Authors: Anty, Rodolphe; Canivet, Clémence M.; Patouraux, Stéphanie; Ferrari‐Panaia, Patricia; Saint‐Paul, Marie Christine; Huet, Pierre‐Michel; Lebeaupin, Cynthia; Iannelli, Antonio; Gual, Philippe; Tran, Albert
• Is Part Of: Alcoholism. Volume 39:Number 6(2015:Jun.)
• Page Start: 1027
• Page End: 1033
• Publication Date: 2015-05-02
• Subjects: Alcoholism -- Periodicals; Alcoholism -- Periodicals; Alcoolisme; Electronic journals; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.861005
• DOI: 10.1111/acer.12728
• Languages: English
• ISSNs: 0145-6008

Abstract

<abstract abstract-type="main" id="acer12728-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="acer12728-sec-0001" sec-type="section"> <title>Background</title> <p>Among its pleiotropic effects, vitamin D may protect the liver from fibrosis and/or inflammation. However, the impact of vitamin D on liver pathology in hepatitis C remains unclear, and very few studies including alcoholic patients with liver pathologies have been performed. Here we compared the levels of 25‐OH vitamin D in the blood of alcoholic patients with the occurrence of alcoholic steatohepatitis (ASH) or bridging fibrosis.</p> </sec> <sec id="acer12728-sec-0002" sec-type="section"> <title>Methods</title> <p>One hundred and one alcoholic patients were included. All the patients received a liver biopsy, and the levels of 25‐OH vitamin D were evaluated with the Liaison 25‐OH vitamin D assay. Logistic regression analyses were performed to obtain predictive factors of liver histology.</p> </sec> <sec id="acer12728-sec-0003" sec-type="section"> <title>Results</title> <p>Among alcoholic patients, 40.6% presented ASH and 39.6% presented bridging fibrosis. A severe deficiency in 25‐OH vitamin D (<10 ng/ml) was seen in 60.4% of patients. This deficiency was frequent in patients with ASH (85.4%) and in those with bridging fibrosis (80%) but was independently associated only with ASH (odds ratio = 8.46 [95% confidence interval 2.05 to 34.89], <italic>p</italic> = 0.003).</p> </sec> <sec id="acer12728-sec-0004" sec-type="section"> <title>Conclusions</title> <p>In alcoholic patients, a severe deficiency in 25‐OH vitamin D was independently associated with the occurrence of ASH.</p> </sec> </abstract>