Outcomes After Liver Transplantation of Patients With Indo-Asian Ethnicity. Issue 4 (April 2015)

• Record Type: Journal Article
• Authors: Rocha, Chiara; Perera, M. Thamara; Roberts, Keith; Bonney, Glenn; Gunson, Bridget; Nightingale, Peter; Bramhall, Simon R.; Isaac, John; Muiesan, Paolo; Mirza, Darius F.
• Is Part Of: Transplantation. Volume 99:Issue 4(2015)
• Publication Date: 2015-04
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; Transplantation immunology -- Periodicals; 617.95
• DOI: 10.1097/TP.0000000000000411
• Languages: English
• ISSNs: 0041-1337

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Background</title> <p>The impact of ethnicity on outcomes after orthotopic liver transplantation (OLT) is unclear. The British Indo-Asian population has a high incidence of liver disease but its contribution to the national deceased donor pool is small. We evaluated access to and outcomes of OLT in Indo-Asians.</p> </sec> <sec> <title>Methods</title> <p>We compared 182 Indo-Asians with white patients undergoing OLT. Matching criteria were transplantation year, liver disease, age, sex. Donor and recipient characteristics, postoperative outcomes, including patient and graft survival, OLT era (early, 1987–2001; late, 2002–2011) were compared. Survival was also analyzed by underlying disease—acute liver failure (ALF) and chronic liver failure.</p> </sec> <sec> <title>Results</title> <p>Indo-Asians had higher diabetes incidence. There were no differences in waiting time for transplantation, despite smaller body size and more uncommon blood groups (B, AB) among Indo-Asians. In the early era, patient survival for Indo-Asians with ALF was worse when compared to whites. In the late era, graft and patient survival at 1, 2, and 5 years were similar between groups.</p> </sec> <sec> <title>Conclusion</title> <p>This study demonstrates that Indo-Asian patients have equal access to OLT and comparable outcomes to whites in the United Kingdom. Survival has improved among Indo-Asian patients; this may be attributable to careful patient selection in case of ALF, though improvement of patient management may have contributed.</p> </sec> </abstract>