Usefulness of Dual-Phase 18F-FDG PET/CT for Diagnosing Small Pancreatic Tumors. Issue 4 (May 2015)

• Record Type: Journal Article
• Authors: Kawada, Natsuko; Uehara, Hiroyuki; Hosoki, Takuya; Takami, Motohisa; Shiroeda, Hisakazu; Arisawa, Tomiyasu; Tomita, Yasuhiko
• Is Part Of: Pancreas. Volume 44:Issue 4(2015)
• Publication Date: 2015-05
• Subjects: Pancreas -- Diseases -- Periodicals; Pancreas -- Periodicals; Neuroendocrine tumors -- Periodicals; 616.37005
• DOI: 10.1097/MPA.0000000000000313
• Languages: English
• ISSNs: 0885-3177

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Objectives</title> <p>The usefulness of dual-phase <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>F-FDG) positron emission tomography/computed tomography (PET/CT) for pancreatic tumors was investigated including numerous small tumors.</p> </sec> <sec> <title>Methods</title> <p>Consecutive 116 patients with solid pancreatic tumors were subjected. Maximum standard uptake values (SUV<sub>max</sub>) at 1 and 2 hours after FDG injection were defined as early and delayed SUV<sub>max</sub>, respectively. Receiver operating characteristic curve was used to determine the optimal cutoff value of early SUV<sub>max</sub>. Diagnostic accuracy of dual-phase FDG PET/CT was compared with that of single phase.</p> </sec> <sec> <title>Results</title> <p>The mean ± SD tumor size was 25 ±12 mm in diameter. The level of early SUV<sub>max</sub> and proportion of elevated SUV<sub>max</sub> in delayed phase were significantly higher in malignancy than those in benignancy for less than 25 mm tumors (4.1 ± 2.6 vs 1.9 ± 0.5, <italic>P</italic> < 0.001; 89% vs 17%, <italic>P</italic> < 0.0001) although they did not reach statistical significance for greater than or equal to 25 mm tumors. When diagnostic criteria of dual-phase FDG PET/CT for less than 25 mm tumors were determined as (1) early SUV<sub>max</sub> greater than or equal to 2.1 and/or (2) delayed SUV<sub>max</sub> greater than early SUV<sub>max</sub>, sensitivity, specificity, and over all accuracy of dual-phase FDG PET/CT were better than that of single phase for less than 25 mm tumor (93%, 83%, and 91% vs 79%, 83%, and 80%, respectively).</p> </sec> <sec> <title>Conclusions</title> <p>Dual-phase FDG PET/CT might be useful for diagnosing small pancreatic tumors.</p> </sec> </abstract>