A Case of Atypical Adult-onset Tic Disorder. Issue 4 (April 2015)

• Record Type: Journal Article
• Authors: Colosimo, Carlo
• Is Part Of: Neurologist. Volume 19:Issue 4(2015)
• Publication Date: 2015-04
• Subjects: Nervous System Diseases -- Periodicals; Nervous system -- Diseases -- Periodicals; Neurologie; 616.8
• DOI: 10.1097/NRL.0000000000000023
• Languages: English
• ISSNs: 1074-7931

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Introduction:</title> <p>The differential diagnosis of adult tic disorder is complex, and several common and uncommon causes have to be taken into consideration.</p> </sec> <sec> <title>Case Report:</title> <p>A 30-year-old man came to our movement disorders clinic with multiple tics which had begun insidiously about 10 years earlier. No family history was reported, but his 65-year-old otherwise healthy father also had very subtle involuntary movements. A diagnosis of atypical Gilles de la Tourette syndrome was made. However, the neurological and psychiatric symptoms of the patient rapidly progressed over the following 2 years, resulting in increasingly severe involuntary movements and profound mood disorder. Further diagnostic tests were performed, and a genetic screening for Huntington disease revealed 45 repeats of the CAG nucleotide in the <italic>IT-15</italic> gene.</p> </sec> <sec> <title>Conclusion:</title> <p>This case underlines the marked phenotypic variability of Huntington disease at presentation, including the presence of involuntary movements different from chorea and possibility of an apparently sporadic disorder.</p> </sec> </abstract>