The Protective Effect of Capparis ovata on 6-Mercaptopurine-induced Hepatotoxicity and Oxidative Stress in Rats. Issue 4 (May 2015)

• Record Type: Journal Article
• Authors: Tülümen, Tuğçe; Ayata, Ali; Özen, Metehan; Sütçü, Recep; Canatan, Duran
• Is Part Of: Journal of pediatric hematology/oncology. Volume 37:Issue 4(2015)
• Publication Date: 2015-05
• Subjects: Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000000288
• Languages: English
• ISSNs: 1077-4114

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <p> <italic>Capparis ovata</italic> is a member of Capparidacaeae family has been used in phytomedicine with a lot of positive effects such as an antioxidative, antihyperlipidemic, anti-inflammatory, and antihepatotoxic agent. The aim of this study was to research the protective effect of <italic>C. ovata</italic> on 6-mercaptopurine (6-MP) induced to hepatotoxicity and oxidative stress in rats. The rats were divided into 4 groups: control, 6-MP, <italic>C. ovata</italic>ovate, and 6-MP+<italic>C. ovata</italic>. A complete blood count was performed, liver function test and antioxidant enzymes levels such as superoxide dismutase, glutathione peroxidase, catalase, and malondialdehyde were measured in blood before and after a 14-day test period. White blood cell and platelet counts were lower in the 6-MP group than other 3 groups (<italic>P</italic><0.005). Hepatic transaminase levels were higher in 6-MP group than the 3 groups (<italic>P</italic><0.05). Superoxide dismutase, glutathione peroxidase, and CAT levels were lower and malondialdehyde was higher in blood samples in 6-MP group than other 3 groups (<italic>P</italic><0.005). In conclusion, our tests were showed that <italic>C. ovata</italic> may be useful in patients receiving 6-MP therapy to prevent hepatotoxicity and in order to maintain uninterrupted therapy possibly reducing the risk of relapse. Although additional studies ensure that Capparis does not affect 6-MP antileukemic activity. We believe these results are important contribution to the literature.</p> </sec> </abstract>