GWAS-Identified Common Variants With Nonalcoholic Fatty Liver Disease in Chinese Children. Issue 5 (May 2015)

• Record Type: Journal Article
• Authors: Shang, Xiao-Rui; Song, Jie-Yun; Liu, Fang-Hong; Ma, Jun; Wang, Hai-Jun
• Is Part Of: Journal of pediatric gastroenterology and nutrition. Volume 60:Issue 5(2015)
• Publication Date: 2015-05
• Subjects: Children -- Nutrition -- Periodicals; Pediatric gastroenterology -- Periodicals; Infants -- Nutrition -- Periodicals; Nutrition disorders in children -- Periodicals; Child Nutrition -- Periodicals; Digestive System -- growth & development -- Periodicals; Gastrointestinal Diseases -- Periodicals; Infant Nutrition -- Periodicals; Nutrition Disorders -- Periodicals; Child; 618.923
• DOI: 10.1097/MPG.0000000000000662
• Languages: English
• ISSNs: 0277-2116

Abstract

<abstract> <title>ABSTRACT</title> <sec> <title>Objectives:</title> <p>Three genome-wide association studies were previously done for nonalcoholic fatty liver disease (NAFLD) among individuals of Western countries and identified several genetic variants associated with NAFLD. The study aimed to identify whether 7 GWAS-identified common variants (<italic>GCKR</italic> rs780094, <italic>PDGFA</italic> rs343064, <italic>FDFT1</italic> rs2645424, <italic>COL13A1</italic> rs1227756, <italic>EHBP1L1</italic> rs6591182, <italic>NCAN</italic> rs2228603, and <italic>PNPLA3</italic> rs738409) were associated with NAFLD in Chinese children.</p> </sec> <sec> <title>Methods:</title> <p>This case-control study recruited 1027 Chinese children of age 7 to 18 years, including 162 children with NAFLD and 865 children without NAFLD. Anthropometric measurements, alanine transaminase (ALT) detection, liver ultrasound examination, and genotyping of 7 variants were performed.</p> </sec> <sec> <title>Results:</title> <p>The G-allele of <italic>PNPLA3</italic> rs738409 was associated with NAFLD (odds ratio [OR] 1.55, 95% confidence interval 1.13–2.11, <italic>P</italic> = 0.006) and moderate-to-severe steatosis (OR 3.77, 95% confidence interval 1.78–7.98, <italic>P</italic> = 0.001) adjusted for age, sex, and BMI standard deviation score. In addition, we found each G-allele of rs738409 increased ALT level by 1.09 IU/L (<italic>P</italic> = 0.011). Subjects carrying 10 or more risk alleles of 7 variants had an OR of 4.76 (<italic>P</italic> = 0.025) for NAFLD compared with subjects carrying 3 or fewer risk alleles.</p> </sec> <sec> <title>Conclusions:</title> <p>The <italic>PNPLA3</italic> rs738409 G-allele was associated with NAFLD and ALT level in Chinese children. It had stronger association with moderate-to-severe steatosis. Children carrying 10 or more risk alleles of 7 variants were susceptible for NAFLD.</p> </sec> </abstract>