Serum Salusin-β Levels Are Associated With the Presence and Severity of Coronary Artery Disease. Issue 4 (April 2015)

• Record Type: Journal Article
• Authors: Liu, Jun; Ren, Yin-gang; Zhang, Li-hua; Tong, Ya-wen; Kang, Li
• Is Part Of: Journal of investigative medicine. Volume 63:Issue 4(2015:Apr.)
• Publication Date: 2015-04
• Subjects: Clinical medicine -- Periodicals; Medicine -- Research -- Periodicals; Medicine; Research -- United States; Clinical medicine; Medicine -- Research; Periodicals; 616.075
• DOI: 10.1097/JIM.0000000000000184
• Languages: English
• ISSNs: 1081-5589

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Objectives</title> <p>We sought to assess whether serum salusin-β levels are correlated with the presence and severity of coronary artery disease (CAD).</p> </sec> <sec> <title>Methods</title> <p>We measured serum salusin-β levels in 278 consecutive patients undergoing coronary angiography (CAG) for the evaluation of CAD and in 126 healthy controls. Serum salusin-β levels were measured by enzyme-linked immunosorbent assay. The severity of CAD was assessed by angiographic coronary atherosclerosis index score system.</p> </sec> <sec> <title>Results</title> <p>Serum salusin-β levels were significantly higher in patients undergoing CAG (n = 278) than those in healthy controls (n = 126) (3.81 ± 0.99 vs 4.34 ± 1.40 nmol/L, <italic>P</italic> < 0.01). In patients undergoing CAG, patients with CAD (n = 160) had significantly higher serum salusin-β levels compared to patients without CAD (n = 118) (4.65 ± 1.44 vs 3.94 ± 1.23 nmol/L, <italic>P</italic> < 0.01). Multivariate logistic regression analysis revealed that serum salusin-β levels were independently associated with the presence of CAD (odds ratio, 1.439; 95% confidence interval, 1.176–1.760; <italic>P</italic> < 0.01). Serum salusin-β levels were positively correlated with the coronary atherosclerosis index score (r = 0.316, <italic>P</italic> < 0.001).</p> </sec> <sec> <title>Conclusions</title> <p>Serum salusin-β levels were associated with the presence and severity of CAD. Salusin-β in serum might serve as a potential biomarker for reflecting the development and progression of CAD. Therapeutic treatment by inhibiting salusin-β interaction to prevent CAD warrants further investigation.</p> </sec> </abstract>