Role of masked coronary heart disease in patients with recent-onset atrial fibrillation and troponin elevations. (June 2015)

• Record Type: Journal Article
• Authors: Conti, Alberto; Mariannini, Yuri; Canuti, Erica; Cerini, Gabriele; De Bernardis, Niccolò; Gigli, Chiara; Giampieri, Margherita; Viviani, Gabriele; Poggioni, Claudio; Padeletti, Luigi
• Is Part Of: European journal of emergency medicine. Volume 22:Number 3(2015)
• Publication Date: 2015-06
• Subjects: Emergency medicine -- Europe -- Periodicals; Medical emergencies -- Europe -- Periodicals; Emergency medical services -- Europe -- Periodicals; Emergencies -- Europe -- Periodicals; Emergency Medical Services -- Europe -- Periodicals; Emergency Medicine -- Europe -- periodicals; 616.025
• DOI: 10.1097/MEJ.0000000000000130
• Languages: English
• ISSNs: 0969-9546

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Background</title> <p>Patients with recent-onset atrial fibrillation (AF) and cardiac troponin I (cTnI) elevations show poor outcomes. Coronary heart disease might be a cause, consequence, or an innocent bystander.</p> </sec> <sec> <title>Objective</title> <p>The aim of this study was to recognize and treat coronary heart disease to avoid adverse events.</p> </sec> <sec> <title>Methods</title> <p>Patients with recent-onset AF participated in the study. The exclusion criteria were acute coronary syndrome and severe comorbidities. Patients managed with standard care (group 1, <italic>n</italic>=1086, years 2010–2011) were compared with patients managed with tailored care inclusive of echocardiography and stress testing when required (group 2, <italic>n</italic>=1055, years 2012–2013).</p> </sec> <sec> <title>Endpoint</title> <p>The endpoint was a composite of ischemic vascular events including stroke, acute coronary syndrome, revascularization and cardiovascular death at 6 months of follow-up.</p> </sec> <sec> <title>Results</title> <p>Of 4008 patients considered, 2141 were enrolled; 183 showed cTnI elevations, 92 in group 1 and 91 in group 2. cTnI elevations, known ischemic heart disease and age were predictors of the endpoint on multivariate analysis. Overall, two versus seven patients (<italic>P</italic>=0.033) in groups 1 and 2, respectively, underwent revascularization. Eventually, 16 patients in group 1 versus five patients in group 2 reached the endpoint (<italic>P</italic>=0.019). Patients of group 2 were managed as follow: 35 were admitted, 15 with positive stress testing and 20 with high cTnI values (mean values: 0.64±1.01 ng/ml). Fifty-six patients were discharged with negative stress testing results (<italic>n</italic>=13) or very low cTnI values (<italic>n</italic>=43, mean values 0.29±0.30 ng/ml).</p> </sec> <sec> <title>Conclusion</title> <p>In patients with AF and cTnI elevations, tailored care inclusive of echocardiography and stress testing succeeded in recognizing and treating masked 'critical' coronary heart disease, avoiding adverse events.</p> </sec> </abstract>