Significance of premature progesterone rise in IVF. Issue 3 (June 2015)

• Record Type: Journal Article
• Authors: Fatemi, Human M.; Van Vaerenbergh, Inge
• Is Part Of: Current opinion in obstetrics and gynecology. Volume 27:Issue 3(2015:Jun.)
• Publication Date: 2015-06
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; Genital Diseases, Female -- Indexes; Genital Diseases, Female -- Periodicals; Obstetrics -- Indexes; Obstetrics -- Periodicals; Review Literature -- Periodicals; 618.005
• DOI: 10.1097/GCO.0000000000000172
• Languages: English
• ISSNs: 1040-872X

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Purpose of review</title> <p>The current review will focus on the cause of premature progesterone and its impact on endometrial receptivity and endometrial gene expression.</p> </sec> <sec> <title>Recent findings</title> <p>Premature progesterone rise in stimulated IVF cycles seems to have a negative impact on the pregnancy rate. The current knowledge on the cause of a premature progesterone rise is still limited; however, it seems that overstimulating the ovaries during the end of the follicular phase will lead to a premature progesterone rise. The negative impact on the outcome is mainly due to reduced endometrial receptivity as can be seen in the altered endometrial gene expression.</p> </sec> <sec> <title>Summary</title> <p>Future studies should focus on how ovarian stimulation can be tailored according to individual requirements of the patients, aiming on preventing a possible progesterone rise during follicular phase of stimulated IVF cycles.</p> </sec> </abstract>