Myocardial Adaptation to High-Intensity (Interval) Training in Previously Untrained Men With a Longitudinal Cardiovascular Magnetic Resonance Imaging Study (Running Study and Heart Trial). (April 2015)

• Record Type: Journal Article
• Authors: Scharf, Michael; Schmid, Axel; Kemmler, Wolfgang; von Stengel, Simon; May, Matthias S.; Wuest, Wolfgang; Achenbach, Stephan; Uder, Michael; Lell, Michael M.
• Is Part Of: Circulation. Volume 8:Number 4(2015)
• Publication Date: 2015-04
• Subjects: Cardiovascular system -- Imaging -- Periodicals; Heart -- Imaging -- Periodicals; 616.1075405
• DOI: 10.1161/CIRCIMAGING.114.002566
• Languages: English
• ISSNs: 1941-9651

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Background—</title> <p>To prospectively evaluate whether short-term high-intensity (interval) training (HI(I)T) induces detectable morphological cardiac changes in previously untrained men in cardiovascular magnetic resonance imaging.</p> </sec> <sec> <title>Methods and Results—</title> <p>Eighty-four untrained volunteers were randomly assigned to a HI(I)T group (n=42; 44.1±4.7 years) or an inactive control group (n=42; 42.3±5.6 years). HI(I)T focused on interval runs (intensity: 95%–105% of individually calculated heart rate at the anaerobic threshold). Before and after 16 weeks, all subjects underwent physiological examination, stepwise treadmill test with blood lactate analysis, and contrast-enhanced cardiovascular magnetic resonance imaging (cine, tagging, and delayed enhancement). Indexed left ventricular (LV) and right ventricular (RV) volume (LV, 77.1±8.5–83.9±8.6; RV, 80.5±8.5–86.6±8.1) and mass (LV, 58.2±6.4–63.4±8.1; RV, 14.8±1.7–16.1±2.1) significantly increased with HI(I)T. Changes in LV and RV morphological parameters with HI(I)T were highly correlated with an increase in maximal aerobic capacity (VO<sub>2max</sub>) and a decrease in blood lactate concentration at the anaerobic threshold. Mean LV and RV remodeling index of HI(I)T group did not alter with training (0.76 ±0.09 and 0.24±0.10 g/mL, respectively [<italic>P</italic>=0.97 and <italic>P</italic>=0.72]), indicating balanced cardiac adaptation. Myocardial circumferential strain decreased after HI(I)T within all 6 basal segments (anteroseptal, <italic>P</italic>=0.01 and anterolateral, <italic>P</italic><0.001). There was no late gadolinium enhancement in any of the participants before or post HI(I)T.</p> </sec> <sec> <title>Conclusions—</title> <p>Sixteen weeks of HI(I)T lead to measurable changes in cardiac atrial and ventricular morphology and function in previously untrained men. This correlates with improvements in parameters of endurance capacity.</p> </sec> <sec> <title>Clinical Trial Registration—</title> <p>URL: <ext-link ext-link-type="uri" xlink:href="http://www.clinicaltrials.gov" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">http://www.clinicaltrials.gov</ext-link>. Unique identifier: NCT01406730.</p> </sec> </abstract>