Radical‐Induced Metal‐Free Alkynylation of Aldehydes by Direct CH Activation. Issue 24 (29th April 2015)

• Record Type: Journal Article
• Authors: Liu, Xuesong; Yu, Linqian; Luo, Mupeng; Zhu, Jidong; Wei, Wanguo
• Is Part Of: Chemistry. Volume 21:Issue 24(2015)
• Page Start: 8745
• Page End: 8749
• Publication Date: 2015-04-29
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201501094
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A direct C(sp²)H alkynylation of aldehyde C(O)H bonds with hypervalent iodine alkynylation reagents provides ynones under metal‐free conditions. In this method, 1‐[(triisopropylsilyl)ethynyl]‐1, 2‐benziodoxol‐3(1<italic>H</italic>)‐one (TIPS‐EBX) constitutes an efficient alkynylation reagent for the introduction of the triple bond. The substrate scope is extended to a variety of (hetero)aromatic, aliphatic, and α, β‐unsaturated aldehydes.</p> </abstract>