Enantiogroup‐Differentiating Biocatalytic Reductions of Prochiral Cs‐Symmetrical Dicarbonyl Compounds to meso Compounds. Issue 24 (27th April 2015)

• Record Type: Journal Article
• Authors: Skoupi, Marc; Vaxelaire, Carine; Strohmann, Carsten; Christmann, Mathias; Niemeyer, Christof M.
• Is Part Of: Chemistry. Volume 21:Issue 24(2015)
• Page Start: 8701
• Page End: 8705
• Publication Date: 2015-04-27
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201500741
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The stereoselective reduction of symmetrical prochiral dicarbonyl compounds bearing enantiotopic carbonyl groups yields several stereogenic centers in one step. In a proof‐of‐concept study, a new approach is described for the enzymatic desymmetrization of 5‐nitrononane‐2, 8‐dione via sequential biocatalytic reduction steps utilizing ketoreductases to yield all possible diastereomers of 5‐nitrononane‐2, 8‐diol.</p> </abstract>