The functional roles of the three copper sites associated with the methionine-rich insert in the multicopper oxidase CueO from E. coli1. Issue 5 (13th May 2015)

• Record Type: Journal Article
• Authors: Cortes, Laura; Wedd, Anthony G.; Xiao, Zhiguang
• Is Part Of: Metallomics. Volume 7:Issue 5(2015:May)
• Page Start: 776
• Page End: 785
• Publication Date: 2015-05-13
• Subjects: Metals -- Physiological effect -- Periodicals; 572.51
• DOI: 10.1039/c5mt00001g
• Languages: English
• ISSNs: 1756-5901

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgjp09hcn3" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />The methionine-rich insert in the multicopper oxidase CueO from <italic>E. coli</italic> accommodates three copper sites that play distinct but related roles in Cu(<sc>i</sc>) extraction and oxidation and that induce robust cuprous oxidase activity under physiologically relevant conditions.</p> </abstract>