A dual radiolabelling approach for tracking metal complexes: investigating the speciation of copper bis(thiosemicarbazonates) in vitro and in vivo1. Issue 5 (13th May 2015)

• Record Type: Journal Article
• Authors: Hueting, Rebekka; Kersemans, Veerle; Tredwell, Matthew; Cornelissen, Bart; Christlieb, Martin; Gee, Antony D.; Passchier, Jan; Smart, Sean C.; Gouverneur, Véronique; Muschel, Ruth J.; Dilworth, Jonathan R.
• Is Part Of: Metallomics. Volume 7:Issue 5(2015:May)
• Page Start: 795
• Page End: 804
• Publication Date: 2015-05-13
• Subjects: Metals -- Physiological effect -- Periodicals; 572.51
• DOI: 10.1039/c4mt00330f
• Languages: English
• ISSNs: 1756-5901

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgjp09hbm3" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />A pair of [¹²³I]/[⁶⁴Cu]-copper bis(thiosemicarbazonates), radiolabelled at either the <italic>metal</italic> or at the <italic>ligand</italic>, was used to examine the roles of the copper metal and the ligand in the <italic>in vitro</italic> and <italic>in vivo</italic> behaviour of this class of hypoxia PET imaging agent.</p> </abstract>