Acid-labile polyrotaxane exerting endolysosomal pH-sensitive supramolecular dissociation for therapeutic applications. Issue 21 (7th June 2015)

• Record Type: Journal Article
• Authors: Nishida, Kei; Tamura, Atsushi; Yui, Nobuhiko
• Is Part Of: Polymer chemistry. Volume 6:Issue 21(2015)
• Page Start: 4040
• Page End: 4047
• Publication Date: 2015-06-07
• Subjects: Polymers -- Periodicals; Macromolecules -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1039/c5py00445d
• Languages: English
• ISSNs: 1759-9954

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgjp073pzw" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />For achieving pH-sensitive dissociation and the subsequent release of threaded cyclic molecules from polyrotaxanes (PRXs) in weakly acidic environments, a novel acid-labile Pluronic/β-cyclodextrin-based PRX bearing ketal linkages was designed and its potential biomedical application was demonstrated.</p> </abstract>