Lymph node ratio influence on risk of head and neck cancer locoregional recurrence after initial surgical resection: Implications for adjuvant therapy. Issue 6 (30th April 2014)

• Record Type: Journal Article
• Authors: Prabhu, Roshan S.; Hanasoge, Sheela; Magliocca, Kelly R.; Hall, William A.; Chen, Susie A.; Higgins, Kristin A.; Saba, Nabil F.; El‐Deiry, Mark; Grist, William; Wadsworth, J. Trad; Chen, Amy Y.; Beitler, Jonathan J.
• Is Part Of: Head & neck. Volume 37:Issue 6(2015:Jun.)
• Page Start: 777
• Page End: 782
• Publication Date: 2014-04-30
• Subjects: Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.23662
• Languages: English
• ISSNs: 1043-3074

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="hed23662-sec-0001" sec-type="section"> <title>Background</title> <p>The purpose of this study was to determine if lymph node ratio is associated with locoregional recurrence for patients with oral cavity or laryngeal cancer treated with initial surgical management.</p> </sec> <sec id="hed23662-sec-0002" sec-type="section"> <title>Methods</title> <p>The study included 350 patients with oral cavity (73%) or laryngeal cancer (27%) who underwent initial surgery. All analyses were multivariable, adjusting for primary site, pathologic prognostic factors, and adjuvant therapy.</p> </sec> <sec id="hed23662-sec-0003" sec-type="section"> <title>Results</title> <p>Lymph node ratio was significantly associated with locoregional recurrence, in which each 1% increase in lymph node ratio had an adjusted hazard ratio (HR) for locoregional recurrence of 1.02 (95% confidence interval [CI], 1.002–1.042; <italic>p</italic> = .05). Lymph node ratio was also associated with OS, in which each 1% increase in lymph node ratio had an adjusted HR for death of 1.028 (95% CI, 1.012–1.045; <italic>p</italic> = .001).</p> </sec> <sec id="hed23662-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Adjusting for pathologic factors and adjuvant therapy, lymph node ratio was found to be an independent prognostic factor for locoregional recurrence and overall survival (OS). Patients with lymph node ratio ≥20% are at high risk of locoregional recurrence and death, and may be considered for adjuvant chemoradiation. © 2014 Wiley Periodicals, Inc. <italic>Head Neck</italic> 37: 777–782, 2015</p> </sec> </abstract>