Short‐term prognostic factors for primary sclerosing cholangitis. (31st March 2015)
- Record Type:
- Journal Article
- Title:
- Short‐term prognostic factors for primary sclerosing cholangitis. (31st March 2015)
- Main Title:
- Short‐term prognostic factors for primary sclerosing cholangitis
- Authors:
- Watanabe, Takeo
Hirano, Kenji
Tada, Minoru
Isayama, Hiroyuki
Mizuno, Suguru
Arizumi, Toshihiko
Toda, Nobuo
Sugawara, Yasuhiko
Kokudo, Norihiro
Koike, Kazuhiko - Abstract:
- <abstract abstract-type="main"> <title>Abstract</title> <sec id="jhbp238-sec-0001" sec-type="section"> <title>Background</title> <p>It was recently reported that alkaline phosphatase (ALP) levels below 1.5 upper limit of normal (ULN) predicted better prognosis in primary sclerosing cholangitis (PSC). We evaluated whether ALP as well as other laboratory values were useful for the short‐term prognosis of PSC in a Japanese cohort.</p> </sec> <sec id="jhbp238-sec-0002" sec-type="section"> <title>Methods</title> <p>In 78 patients with PSC (41 males and 37 females, mean onset age 41.9 years), the relationship between nine parameters (albumin, bilirubin, international normalized ratio of prothrombin time [PT‐INR], ALP, aspartate aminotransferase [AST], alanine aminotransferase [ALT], γ‐glutamyl transpeptidase [γ‐GTP], platelet, and calculated Model for End‐Stage Liver Disease [MELD] score), and liver related clinical endpoints (death due to liver failure, variceal bleeding, liver transplantation, and biliary carcinoma) were retrospectively examined. Using receiver operating characteristic (ROC) analysis, we investigated which parameter was useful for predicting the short‐term prognosis.</p> </sec> <sec id="jhbp238-sec-0003" sec-type="section"> <title>Results</title> <p>Average follow‐up period was 8.6 years. The endpoints were evaluated in 40 patients. Seven patients died of liver failure, three patients developed variceal bleeding, nine patients received liver transplantation from<abstract abstract-type="main"> <title>Abstract</title> <sec id="jhbp238-sec-0001" sec-type="section"> <title>Background</title> <p>It was recently reported that alkaline phosphatase (ALP) levels below 1.5 upper limit of normal (ULN) predicted better prognosis in primary sclerosing cholangitis (PSC). We evaluated whether ALP as well as other laboratory values were useful for the short‐term prognosis of PSC in a Japanese cohort.</p> </sec> <sec id="jhbp238-sec-0002" sec-type="section"> <title>Methods</title> <p>In 78 patients with PSC (41 males and 37 females, mean onset age 41.9 years), the relationship between nine parameters (albumin, bilirubin, international normalized ratio of prothrombin time [PT‐INR], ALP, aspartate aminotransferase [AST], alanine aminotransferase [ALT], γ‐glutamyl transpeptidase [γ‐GTP], platelet, and calculated Model for End‐Stage Liver Disease [MELD] score), and liver related clinical endpoints (death due to liver failure, variceal bleeding, liver transplantation, and biliary carcinoma) were retrospectively examined. Using receiver operating characteristic (ROC) analysis, we investigated which parameter was useful for predicting the short‐term prognosis.</p> </sec> <sec id="jhbp238-sec-0003" sec-type="section"> <title>Results</title> <p>Average follow‐up period was 8.6 years. The endpoints were evaluated in 40 patients. Seven patients died of liver failure, three patients developed variceal bleeding, nine patients received liver transplantation from a living donor, 13 patients received certified brain‐dead liver transplantation, and eight patients developed biliary carcinoma. The parameters with an area under the curve (AUC) of more than 0.8 were albumin, bilirubin, PT‐INR, ALP, and MELD score. AUC for ALP was 0.85. The optimal cutoff value was 2.3 ULN. Despite the use or non‐use of ursodeoxycholic acid, short‐term prognosis of patients with an ALP level below 2.3 ULN was good.</p> </sec> <sec id="jhbp238-sec-0004" sec-type="section"> <title>Conclusions</title> <p>We confirmed that keeping ALP low is associated with better short‐term prognosis in a Japanese cohort. In addition, Alb, Bil, PT‐INR, and MELD score were good predictors.</p> </sec> </abstract> … (more)
- Is Part Of:
- Journal of hepato-biliary-pancreatic sciences. Volume 22:Number 6(2015)
- Journal:
- Journal of hepato-biliary-pancreatic sciences
- Issue:
- Volume 22:Number 6(2015)
- Issue Display:
- Volume 22, Issue 6 (2015)
- Year:
- 2015
- Volume:
- 22
- Issue:
- 6
- Issue Sort Value:
- 2015-0022-0006-0000
- Page Start:
- 486
- Page End:
- 490
- Publication Date:
- 2015-03-31
- Subjects:
- Liver -- Diseases -- Periodicals
Biliary tract -- Diseases -- Periodicals
Pancreas -- Diseases -- Periodicals
617.556 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1868-6982 ↗
http://www.springerlink.com/content/121581 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/jhbp.238 ↗
- Languages:
- English
- ISSNs:
- 1868-6974
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 4997.660000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 3945.xml