Earlier onset of diabesity‐Induced adverse cardiac remodeling in female compared to male mice. (9th May 2015)

• Record Type: Journal Article
• Authors: Bowden, Marissa A.; Tesch, Greg H.; Julius, Tracey L.; Rosli, Sarah; Love, Jane E.; Ritchie, Rebecca H.
• Is Part Of: Obesity. Volume 23:Number 6(2015:Jun.)
• Page Start: 1166
• Page End: 1177
• Publication Date: 2015-05-09
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.21072
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby21072-sec-0001" sec-type="section"> <title>Objective</title> <p>Emerging evidence suggests female type 2 diabetes (T2DM) patients may fare worse than males with respect to cardiovascular complications. Hence the impact of sex on relative progression of left ventricular (LV) remodeling in obese <italic>db/db</italic> mice was characterized.</p> </sec> <sec id="oby21072-sec-0002" sec-type="section"> <title>Methods</title> <p>The changes in parameters of LV hypertrophy (heart weight, pro‐hypertrophic gene expression, cardiomyocyte size) and fibrosis (LV collagen deposition and oxidative stress), in parallel with body weight and blood glucose and lipid profiles, in male and female <italic>db/db</italic> T2DM mice, at 10, 14, and 18 weeks of age, were determined.</p> </sec> <sec id="oby21072-sec-0003" sec-type="section"> <title>Results</title> <p>Diabesity‐induced cardiac remodeling was at least comparable in female (compared to male) mice. Females exhibited enhanced systemic oxidative stress and nonesterified fatty acid levels. Progression of LV pro‐hypertrophic (β‐myosin heavy chain, B‐type natriuretic peptide) and pro‐oxidant gene expression (NADPH oxidase subunit Nox2, plasminogen activator inhibitor‐1 PAI‐I) was, however, exaggerated in females when expressed relative to 10‐week‐old <italic>db/db</italic> mice. Increased cardiomyocyte width was also evident earlier in <italic>db/db</italic> females than males. No other gender differences were observed.</p> </sec> <sec id="oby21072-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Progressive, age‐dependent development of cardiac remodeling in <italic>db/db</italic> mice parallels impairments in glucose handling and oxidative stress. Certain aspects of the T2DM‐induced LV remodeling response may have an earlier and/or exaggerated onset in diabetic females.</p> </sec> </abstract>