GPRC6a is not required for the effects of a high‐protein diet on body weight in mice. (9th May 2015)

• Record Type: Journal Article
• Authors: Kinsey‐Jones, James S.; Alamshah, Amin; McGavigan, Anne K.; Spreckley, Eleanor; Banks, Katherine; Cereceda Monteoliva, Nicholas; Norton, Mariana; Bewick, Gavin A.; Murphy, Kevin G.
• Is Part Of: Obesity. Volume 23:Number 6(2015:Jun.)
• Page Start: 1194
• Page End: 1200
• Publication Date: 2015-05-09
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.21083
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby21083-sec-0001" sec-type="section"> <title>Objective</title> <p>The G‐protein coupled receptor family C group 6 member A (GPRC6A) is activated by proteinogenic amino acids and may sense amino acids in the gastrointestinal tract and the brain. The study investigated whether GPRC6A was necessary for the effects of low‐ and high‐protein diets on body weight and food intake in mice.</p> </sec> <sec id="oby21083-sec-0002" sec-type="section"> <title>Methods</title> <p>The role of GPRC6A in mediating the effects of a low‐protein diet on body weight was investigated in GPRC6a knockout (GPRC6a‐KO) and wild‐type (WT) mice fed a control diet (18% protein) or a low‐protein diet (6% protein) for 9 days. The role of GPRC6A in mediating the effects of a high‐protein diet on body weight was investigated in GPRC6a‐KO and WT mice fed a control diet (18% protein) or a high‐protein diet (50% protein) for 5 weeks.</p> </sec> <sec id="oby21083-sec-0003" sec-type="section"> <title>Results</title> <p>A high‐protein diet reduced body weight gain and food intake compared with a control diet in both WT and GPRC6a‐KO mice. A low‐protein diet decreased body weight gain in GPRC6a‐KO mice.</p> </sec> <sec id="oby21083-sec-0004" sec-type="section"> <title>Conclusions</title> <p>GPRC6A was not necessary for the effects of a low‐ or high‐protein diet on body weight and likely does not play a role in protein‐induced satiety.</p> </sec> </abstract>