Correlation between Membrane Partitioning and Functional Activity in a Single Lipid Vesicle Assay Establishes Design Guidelines for Antiviral Peptides. Issue 20 (23rd January 2015)

• Record Type: Journal Article
• Authors: Jackman, Joshua A.; Saravanan, Rathi; Zhang, Yibang; Tabaei, Seyed R.; Cho, Nam‐Joon
• Is Part Of: Small. Volume 11:Issue 20(2015)
• Page Start: 2372
• Page End: 2379
• Publication Date: 2015-01-23
• Subjects: Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201403638
• Languages: English
• ISSNs: 1613-6810

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="smll201403638-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The nanometer‐scale discrimination of virus‐rupturing peptides</bold> is tested using lipid membrane platforms. In combination with single‐vesicle analysis of peptide‐induced vesicle rupture, a correlation between membrane partitioning and biologically relevant activities is established. Taken together, the findings support that the degree of rupture activity should be balanced by membrane curvature‐selectivity for optimal therapeutic properties of antiviral peptides. <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgjng66bf6" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>