The Effect of Orally Administered Ranitidine and Once‐Daily or Twice‐Daily Orally Administered Omeprazole on Intragastric pH in Cats. (13th May 2015)

• Record Type: Journal Article
• Authors: Šutalo, S.; Ruetten, M.; Hartnack, S.; Reusch, C.E.; Kook, P. H.
• Is Part Of: Journal of veterinary internal medicine. Volume 29:Number 3(2015:May/Jun.)
• Page Start: 840
• Page End: 846
• Publication Date: 2015-05-13
• Subjects: Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.12580
• Languages: English
• ISSNs: 0891-6640

Abstract

<abstract abstract-type="main" id="jvim12580-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jvim12580-sec-0001" sec-type="section"> <title>Background</title> <p>Gastric acid suppressants frequently are used in cats with acid‐related gastric disorders. However, it is not known if these drugs effectively increase intragastric pH in cats.</p> </sec> <sec id="jvim12580-sec-0002" sec-type="section"> <title>Objectives</title> <p>To examine the effects of PO administered ranitidine and omeprazole on intragastric pH in cats and to compare the efficacy of once‐daily versus twice‐daily dosage regimens for omeprazole.</p> </sec> <sec id="jvim12580-sec-0003" sec-type="section"> <title>Animals</title> <p>Eight domestic shorthair cats.</p> </sec> <sec id="jvim12580-sec-0004" sec-type="section"> <title>Methods</title> <p>Using a randomized 4‐way cross‐over design, cats were given enteric‐coated omeprazole granules (1.1–1.3 mg/kg q24h and q12h), ranitidine (1.5–2.3 mg/kg q12h), and placebo. Intragastric pH was monitored continuously for 96 hours using the Bravo<sup>™</sup> system<xref ref-type="link" rid="jvim12580-note-1001" />, starting on day 4 of treatment, followed by a median washout period of 12 days. Mean percentage of time pH was ≥3 and ≥4 was compared among groups using repeated measures ANOVA.</p> </sec> <sec id="jvim12580-sec-0005" sec-type="section"> <title>Results</title> <p>Mean ± SD percentage of time intragastric pH was ≥3 and ≥4 was 67.0 ± 24.0% and 54.6 ± 26.4% for twice‐daily omeprazole, 24.4 ± 22.8% and 16.8 ± 19.3% for once‐daily omeprazole, 16.5 ± 9.0% and 9.6 ± 5.9% for ranitidine, and 9.4 ± 8.0% and 7.0 ± 6.6% for placebo administration. Twice‐daily omeprazole treatment significantly increased intragastric pH, whereas pH after once‐daily omeprazole and ranitidine treatments did not differ from that of placebo‐treated cats.</p> </sec> <sec id="jvim12580-sec-0006" sec-type="section"> <title>Conclusion and Clinical Importance</title> <p>Only twice‐daily PO administered omeprazole significantly suppressed gastric acidity in healthy cats, whereas once‐daily omeprazole and standard dosages of ranitidine were not effective acid suppressants in cats.</p> </sec> </abstract>