Bacterial Urinary Tract Infections Associated with Transitional Cell Carcinoma in Dogs. (1st May 2015)

• Record Type: Journal Article
• Authors: Budreckis, D.M.; Byrne, B.A.; Pollard, R.E.; Rebhun, R.B.; Rodriguez, C.O.; Skorupski, K.A.
• Is Part Of: Journal of veterinary internal medicine. Volume 29:Number 3(2015:May/Jun.)
• Page Start: 828
• Page End: 833
• Publication Date: 2015-05-01
• Subjects: Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.12578
• Languages: English
• ISSNs: 0891-6640

Abstract

<abstract abstract-type="main" id="jvim12578-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jvim12578-sec-0001" sec-type="section"> <title>Background</title> <p>Urinary tract infections (UTI) are believed to be common in dogs with transitional cell carcinoma (TCC), but incidence and contributing factors have not been reported.</p> </sec> <sec id="jvim12578-sec-0002" sec-type="section"> <title>Objectives</title> <p>To determine the frequency and bacterial agents associated with UTI in dogs with TCC and define contributing factors.</p> </sec> <sec id="jvim12578-sec-0003" sec-type="section"> <title>Animals</title> <p>Eighty‐five dogs with a history of urogenital TCC undergoing treatment with chemotherapy that had at least 1 urine culture performed.</p> </sec> <sec id="jvim12578-sec-0004" sec-type="section"> <title>Methods</title> <p>Medical records and culture results were retrospectively reviewed and ultrasound images were reviewed when available. Clinical factors were evaluated statistically for association with positive culture.</p> </sec> <sec id="jvim12578-sec-0005" sec-type="section"> <title>Results</title> <p>Fifty‐five percent (47/85) of dogs had at least 1 positive culture during the course of treatment. Female dogs (80%, 40/50) were more likely than male dogs (29%, 10/35) to have at least 1 positive culture. Ultrasound examination determined that female dogs were more likely to have urethral (74%, 31/42) or trigonal tumor involvement (71%, 30/42) compared to male dogs (32%, 9/28 and 43%, 12/28, respectively). The most commonly isolated organisms were <italic>Staphylococcus</italic> spp. (23.9%, 29/121) and <italic>Escherichia coli</italic> (19.8%, 24/121). Dogs with urethral involvement of TCC were significantly more likely to have at least 1 positive culture than dogs without urethral involvement (75%, 30/40 versus 30%, 9/30).</p> </sec> <sec id="jvim12578-sec-0006" sec-type="section"> <title>Conclusions</title> <p>Urinary tract infection is common in dogs with TCC highlighting the importance of regular monitoring for bacterial cystitis in dogs with TCC. In addition, clinical factors such as tumor location and sex may be predictive of positive culture and can help clinicians assess the risk of UTI.</p> </sec> </abstract>