Changes in Systolic Blood Pressure over Time in Healthy Cats and Cats with Chronic Kidney Disease. (27th April 2015)

• Record Type: Journal Article
• Authors: Bijsmans, E.S.; Jepson, R.E.; Chang, Y.M.; Syme, H.M.; Elliott, J.
• Is Part Of: Journal of veterinary internal medicine. Volume 29:Number 3(2015:May/Jun.)
• Page Start: 855
• Page End: 861
• Publication Date: 2015-04-27
• Subjects: Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.12600
• Languages: English
• ISSNs: 0891-6640

Abstract

<abstract abstract-type="main" id="jvim12600-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jvim12600-sec-0001" sec-type="section"> <title>Background</title> <p>Hypertension is a common problem in older cats, most often associated with chronic kidney disease (CKD). Cross‐sectional studies have suggested that blood pressure in cats increases with age.</p> </sec> <sec id="jvim12600-sec-0002" sec-type="section"> <title>Hypothesis/Objectives</title> <p>To determine whether blood pressure in cats increases with age and whether this occurs independently of the presence of CKD. To investigate risk factors for developing hypertension.</p> </sec> <sec id="jvim12600-sec-0003" sec-type="section"> <title>Animals/Subjects</title> <p>Two hundred and sixty‐five cats with CKD and 133 healthy cats ≥9 years were retrospectively identified.</p> </sec> <sec id="jvim12600-sec-0004" sec-type="section"> <title>Methods</title> <p>Four groups were created according to status at initial evaluation (CKD or healthy) and blood pressure at the last included visit (normotensive [NT] or developed hypertension [DH]): Healthy‐NT, Healthy‐DH, CKD‐NT and CKD‐DH. Systolic blood pressure (SBP) over time slopes were compared with 0 and between groups. Risk factors for the development of hypertension were investigated, and associations of biochemical and clinical variables with SBP were examined.</p> </sec> <sec id="jvim12600-sec-0005" sec-type="section"> <title>Results</title> <p>Cats that were hypertensive at CKD diagnosis (n = 105) were not included in further analyses. Twenty‐seven cats with CKD and 9 healthy cats developed hypertension ≥3 months after diagnosis of CKD or their first visit. Systolic blood pressure significantly increased with age in all cats (<italic>P</italic> < .001). Healthy cats were at less risk than cats with CKD to become hypertensive (hazard ratio 0.2, <italic>P</italic> < .001), with creatinine being an independent risk factor for the development of hypertension.</p> </sec> <sec id="jvim12600-sec-0006" sec-type="section"> <title>Conclusions and Clinical Importance</title> <p>The high prevalence of hypertension in azotemic cats in this study shows the importance of monitoring of SBP in elderly cats, and in particular in cats with CKD.</p> </sec> </abstract>