Spectophotometric intracutaneous analysis: an investigation on photodamaged skin of immunocompromised patients. (13th October 2014)

• Record Type: Journal Article
• Authors: Stimpfle, D.W.; Serra, A.L.; Wüthrich, R.P.; French, L.E.; Braun, R.P.; Hofbauer, G.F.L.
• Is Part Of: Journal of the European Academy of Dermatology and Venereology. Volume 29:Number 6(2015:Jun.)
• Page Start: 1141
• Page End: 1147
• Publication Date: 2014-10-13
• Subjects: Dermatology -- Periodicals; Sexually transmitted diseases -- Periodicals; 616.5
• DOI: 10.1111/jdv.12771
• Languages: English
• ISSNs: 0926-9959

Abstract

<abstract abstract-type="main" id="jdv12771-abs-0001"> <title>Abstract</title> <sec id="jdv12771-sec-0001" sec-type="section"> <title>Background</title> <p>SIAscopy (Spectrophotometric Intracutaneous Analysis) enables non‐invasive analysis of the skin.</p> </sec> <sec id="jdv12771-sec-0002" sec-type="section"> <title>Objective</title> <p>We wanted to determine whether SIAscopy is able to detect and differentiate the skin chromophores melanin, collagen and haemoglobin and the influence of immunosuppressive drugs and other known risk factors for non‐melanoma skin cancer (NMSC).</p> </sec> <sec id="jdv12771-sec-0003" sec-type="section"> <title>Methods</title> <p>Volunteers and patients were measured by SIAscopy at six spots on sun‐exposed and two spots on sun‐protected skin. Measurements were transformed by SIAmetrics into arbitrary units and statistically analysed.</p> </sec> <sec id="jdv12771-sec-0004" sec-type="section"> <title>Results</title> <p>Melanin was shown to be higher with age (+1.73759 a.u.; <italic>P </italic><<italic> </italic>0.0001), sun exposure (+47.03998 a.u.; <italic>P </italic><<italic> </italic>0.0001), immunosuppression (+10.48526 a.u.; <italic>P </italic><<italic> </italic>0.0001) and lower in males (−26.50952 a.u.; <italic>P </italic><<italic> </italic>0.0001). Collagen was lower with increasing age (−0.29162 a.u.; <italic>P </italic><<italic> </italic>0.0001) and sun exposure (−6.85586 a.u.; <italic>P </italic><<italic> </italic>0.0001) but higher with male sex (+8.34251 a.u.; <italic>P </italic><<italic> </italic>0.0001) and immunosuppression (+5.79171 a.u.; <italic>P </italic>=<italic> </italic>0.0001). Haemoglobin was lower with increasing age (−0.23833 a.u.; <italic>P </italic>=<italic> </italic>0.0005), but higher with male sex (+18.51976 a.u.; <italic>P </italic><<italic> </italic>0.0001) and sun exposure (+13.74523 a.u.; <italic>P </italic><<italic> </italic>0.0001). Haemoglobin content was not associated to immunosuppression.</p> </sec> <sec id="jdv12771-sec-0005" sec-type="section"> <title>Conclusion</title> <p>Our results encourage the use of SIAscopy as a tool to better gauge an individual patient's NMSC risk factors. Further studies should help to better delineate SIAscopy as a prognostic tool.</p> </sec> </abstract>