Clinical use of conditioned media of adipose tissue‐derived stem cells in female pattern hair loss: a retrospective case series study. (16th March 2015)

• Record Type: Journal Article
• Authors: Shin, Hyoseung; Ryu, Hyeong Ho; Kwon, Ohsang; Park, Byung‐Soon; Jo, Seong Jin
• Is Part Of: International journal of dermatology. Volume 54:Number 6(2015:Jun.)
• Page Start: 730
• Page End: 735
• Publication Date: 2015-03-16
• Subjects: Dermatology -- Periodicals; 616.5
• DOI: 10.1111/ijd.12650
• Languages: English
• ISSNs: 0011-9059

Abstract

<abstract abstract-type="main" id="ijd12650-abs-0001"> <title>Abstract</title> <sec id="ijd12650-sec-0001" sec-type="section"> <title>Background</title> <p>Female pattern hair loss (FPHL) is a common disorder but presents severe psychosocial problems in many female patients. Adipose tissue‐derived stem cells (ADSCs) and conditioned media of ADSCs (ADSC‐CM) are reported to promote hair growth <italic>in vitro</italic>. However, there are no clinical reports on the treatment of alopecia using ADSC‐CM.</p> </sec> <sec id="ijd12650-sec-0002" sec-type="section"> <title>Objectives</title> <p>This study evaluates our clinical experience in the use of ADSC‐CM for the treatment of FPHL.</p> </sec> <sec id="ijd12650-sec-0003" sec-type="section"> <title>Methods</title> <p>A retrospective, observational study of outcomes in 27 patients with FPHL treated with ADSC‐CM was performed. To evaluate the efficacy of the treatment, patients' medical records and phototrichographic images were analyzed.</p> </sec> <sec id="ijd12650-sec-0004" sec-type="section"> <title>Results</title> <p>The application of ADSC‐CM showed efficacy in treating FPHL after 12 weeks of therapy. Hair density increased from 105.4 to 122.7 hairs/cm<sup>2</sup> (<italic>P</italic> < 0.001). Hair thickness increased from 57.5 <italic>μ</italic>m to 64.0 <italic>μ</italic>m (<italic>P</italic> < 0.001). None of the patients reported severe adverse reactions.</p> </sec> <sec id="ijd12650-sec-0005" sec-type="section"> <title>Conclusions</title> <p>The application of ADSC‐CM is a potential treatment option for FPHL.</p> </sec> </abstract>