Insulin resistance in patients with post‐adolescent acne. (25th June 2014)

• Record Type: Journal Article
• Authors: Balta, Ilknur; Ekiz, Ozlem; Ozuguz, Pınar; Ustun, Ihsan; Karaca, Semsettin; Dogruk Kacar, Seval; Eksioglu, Meral
• Is Part Of: International journal of dermatology. Volume 54:Number 6(2015:Jun.)
• Page Start: 662
• Page End: 666
• Publication Date: 2014-06-25
• Subjects: Dermatology -- Periodicals; 616.5
• DOI: 10.1111/ijd.12426
• Languages: English
• ISSNs: 0011-9059

Abstract

<abstract abstract-type="main" id="ijd12426-abs-0001"> <title>Abstract</title> <sec id="ijd12426-sec-0001" sec-type="section"> <title>Background</title> <p>Post‐adolescent acne has been defined as acne in a patient aged >25 years. Acne vulgaris first develops at the onset of puberty as a result of hormonal changes. During puberty, there is a transient decline in insulin sensitivity. We hypothesized that insulin resistance might persist after puberty in patients with post‐adolescent acne.</p> </sec> <sec id="ijd12426-sec-0002" sec-type="section"> <title>Objectives</title> <p>This study was conducted in order to investigate the relationship between post‐adolescent acne and insulin resistance.</p> </sec> <sec id="ijd12426-sec-0003" sec-type="section"> <title>Methods</title> <p>The study population comprised 35 patients with post‐adolescent acne and 35 healthy control subjects. The parameters measured were fasting blood glucose, insulin, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), total cholesterol (TC), triglycerides, high‐density lipoprotein cholesterol (HDL‐C), and low‐density lipoprotein cholesterol (LDL‐C). The homeostasis model assessment of insulin resistance (HOMA‐IR) index was calculated for each individual.</p> </sec> <sec id="ijd12426-sec-0004" sec-type="section"> <title>Results</title> <p>No significant differences were observed between patients with post‐adolescent acne and control subjects in fasting blood glucose, fasting insulin, AST, ALT, triglyceride and HDL‐C levels, and HOMA‐IR index. There were also no correlations between these parameters and the severity of acne.</p> </sec> <sec id="ijd12426-sec-0005" sec-type="section"> <title>Conclusions</title> <p>This study suggests that insulin resistance may not play a major role in the pathogenesis of post‐adolescent acne. Hormonal changes, genetic susceptibility, stress, the use of cosmetics, drugs, and environmental factors should be considered in the development of post‐adolescent acne.</p> </sec> </abstract>