A stepwise approach for peroral endoscopic myotomy for treating achalasia: from animal models to patients. (August 2014)

• Record Type: Journal Article
• Authors: Ren, Yutang; Tang, Xiaowei; Zhi, Fachao; Liu, Side; Wu, Jianuan; Peng, Yang; Jiang, Bo; Gong, Wei
• Is Part Of: Scandinavian journal of gastroenterology. Volume 50:Number 8(2015)
• Page Start: 952
• Page End: 958
• Publication Date: 2014-08
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; 616.33
• DOI: 10.3109/00365521.2014.983152
• Languages: English
• ISSNs: 0036-5521

Abstract

<abstract> <title>Abstract</title> <p> <bold> <italic>Objectives.</italic> </bold> Peroral endoscopic myotomy (POEM) was initially developed for the treatment of achalasia. This study aimed to investigate the feasibility and safety of a stepwise approach for POEM in the management of achalasia. <bold><italic>Methods.</italic></bold> A total of five <italic>ex-vivo</italic> porcine esophagus-stomach training models were created and POEM was performed. Then, 25 patients with achalasia were treated similarly. The Eckardt score, barium esophagrams, and high-resolution manometry were used to evaluate its efficacy. <bold><italic>Results.</italic></bold> POEM procedures were completed in five stomach-esophagus models, with perforations in the initial three and success in the last two. A total of 25 achalasia patients (13 males, 12 females) with achalasia successfully underwent POEM. The mean operation time was 72.0 min (range, 45–180 min). There were two complications—one case each of severe bleeding and pneumothorax—that were both treated successfully. During the follow-up period, the median Eckardt score decreased dramatically from 8 to 1 (<italic>p</italic> = 0.000). The lower basal esophageal sphincter pressure decreased markedly (41.3 ± 12.6 vs. 11.3 ± 4.3 mmHg, <italic>p</italic> = 0.000), as well as the 4-s integrated relaxation pressure (37.1 ± 12.6 vs. 7.1 ± 2.4 mmHg, <italic>p</italic> = 0.000). Additionally, the maximum esophagus width was significantly reduced (mean reduced width: 1.6 ± 1.1 cm, <italic>p</italic> = 0.000). <bold><italic>Conclusions.</italic></bold> The <italic>ex-vivo</italic> porcine esophagus-stomach can be used as a simple and cheap training model that mimics the POEM procedure. POEM is a safe and effective therapy for achalasia patients.</p> </abstract>