Inside Cover: Rational Design of Ruthenium Complexes Containing 2, 6‐Bis(benzimidazolyl)pyridine Derivatives with Radiosensitization Activity by Enhancing p53 Activation (ChemMedChem 6/2015). Issue 6 (June 2015)

• Record Type: Journal Article
• Authors: Deng, Zhiqin; Yu, Lianling; Cao, Wenqiang; Zheng, Wenjie; Chen, Tianfeng
• Is Part Of: ChemMedChem. Volume 10:Issue 6(2015:Jun.)
• Page Start: 934
• Page End: 934
• Publication Date: 2015-06
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.201590016
• Languages: English
• ISSNs: 1860-7179

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The inside cover picture shows</bold> the rational design of a novel ruthenium complex, Ru(bnbp)₂Cl₂ (where bnbp=2, 6‐bis‐(6‐nitrobenzimidazol‐2‐yl)pyridine). The complex was found to enhance radiation‐induced DNA damage through reactive oxygen species (ROS) overproduction, resulting in cell‐cycle arrest in the G2/M phase and apoptosis, by activating the p53 pathway. This study provides a rational design strategy for developing benzimidazole‐containing ruthenium complexes as potential radiosensitizers. For further details, see the Full Paper by Tianfeng Chen et al. on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">p. 991 ff.</ext-link><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgjnfxmcbt" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>