COMPRES: a prospective postmarketing evaluation of the compression anastomosis ring CAR 27™/ColonRing™. (June 2015)

• Record Type: Journal Article
• Authors: D'Hoore, A.; Albert, M. R.; Cohen, S. M.; Herbst, F.; Matter, I.; Van Der Speeten, K.; Dominguez, J.; Rutten, H.; Muldoon, J. P.; Bardakcioglu, O.; Senagore, A. J.; Ruppert, R.; Mills, S.; Stamos, M. J.; Påhlman, L.; Choman, E.; Wexner, S. D.; the COMPRES collaborative study group
• Is Part Of: Colorectal disease. Volume 17:Number 6(2015)
• Page Start: 522
• Page End: 529
• Publication Date: 2015-06
• Subjects: Colon (Anatomy) -- Diseases -- Periodicals; Rectum -- Diseases -- Periodicals; 616.34
• DOI: 10.1111/codi.12884
• Languages: English
• ISSNs: 1462-8910

Abstract

<abstract abstract-type="main" id="codi12884-abs-0001"> <title>Abstract</title> <sec id="codi12884-sec-0001" sec-type="section"> <title>Aim</title> <p>Preclinical studies have suggested that nitinol‐based compression anastomosis might be a viable solution to anastomotic leak following low anterior resection. A prospective multicentre open label study was therefore designed to evaluate the performance of the ColonRing^™ in (low) colorectal anastomosis.</p> </sec> <sec id="codi12884-sec-0002" sec-type="section"> <title>Method</title> <p>The primary outcome measure was anastomotic leakage. Patients were recruited at 13 different colorectal surgical units in Europe, the United States and Israel. Institutional review board approval was obtained.</p> </sec> <sec id="codi12884-sec-0003" sec-type="section"> <title>Results</title> <p>Between 21 March 2010 and 3 August 2011, 266 patients completed the study protocol. The overall anastomotic leakage rate was 5.3% for all anastomoses, including a rate of 3.1% for low anastomoses. Septic anastomotic complications occurred in 8.3% of all anastomoses and 8.2% of low anastomoses.</p> </sec> <sec id="codi12884-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Nitinol compression anastomosis is safe, effective and easy to use and may offer an advantage for low colorectal anastomosis. A prospective randomized trial comparing ColonRing^™ with conventional stapling is needed.</p> </sec> </abstract>