Cannabinoids suppress acute and anticipatory nausea in preclinical rat models of conditioned gaping. Issue 6 (9th May 2015)

• Record Type: Journal Article
• Authors: Parker, LA; Rock, EM; Sticht, MA; Wills, KL; Limebeer, CL
• Is Part Of: Clinical pharmacology & therapeutics. Volume 97:Issue 6(2015:Jun.)
• Page Start: 559
• Page End: 561
• Publication Date: 2015-05-09
• Subjects: Pharmacology -- Periodicals; Therapeutics -- Periodicals; 615.5
• DOI: 10.1002/cpt.98
• Languages: English
• ISSNs: 0009-9236

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The sensation of nausea is one of the most debilitating human experiences. Current antiemetic therapies are effective in reducing vomiting, but are less effective in reducing acute and delayed nausea and are completely ineffective in reducing anticipatory nausea. Recent preclinical evidence using a selective rat model of nausea (conditioned gaping reactions) has revealed that cannabinoids have great promise as treatments for nausea and that their antinausea effects may be mediated by the interoceptive insular cortex.</p> </abstract>