Joint effect of ADARB1 gene, HTR2C gene and stressful life events on suicide attempt risk in patients with major psychiatric disorders. (June 2015)

• Record Type: Journal Article
• Authors: Karanović, Jelena; Šviković, Saša; Pantović, Maja; Durica, Svetlana; Brajušković, Goran; Damjanović, Aleksandar; Jovanović, Vladimir; Ivković, Maja; Romac, Stanka; Savić Pavićević, Dušanka
• Is Part Of: World journal of biological psychiatry. Volume 16:Number 4(2015)
• Page Start: 261
• Page End: 271
• Publication Date: 2015-06
• Subjects: Biological psychiatry -- Periodicals; Biological Psychiatry -- Periodicals; 616.89
• DOI: 10.3109/15622975.2014.1000374
• Languages: English
• ISSNs: 1562-2975

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objectives.</italic> Adenosine to inosine RNA editing, serotonin 2C receptor (HTR2C), and stressful life events (SLEs) have all been implicated in suicidal behaviour. We examined the main and moderating effects of RNA editing (<italic>ADAR, ADARB1</italic>) and <italic>HTR2C</italic> genes, childhood trauma (CT), recent SLEs and psychiatric disorders as contributors to suicide attempt (SA) vulnerability. <italic>Methods.</italic> Study included 165 suicide attempters and 188 suicide non-attempters, all diagnosed with one of major psychiatric disorders. CT and recent SLEs were assessed using Early Trauma Inventory–Self Report and List of Threatening Experiences Questionnaire, respectively. Selected <italic>ADAR</italic> and <italic>ADARB1</italic> tag-variants, and <italic>HTR2C</italic> rs6318 were pre-screened for association with SA, while generalized linear models and backward selection were applied to identify individual and interacting SA risk factors. <italic>Results. ADARB1</italic> rs9983925 and rs4819035 and <italic>HTR2C</italic> rs6318 were associated with SA. The best minimal model found emotional abuse, recent SLEs, rs9983925 and rs6318 as independent SA risk factors, and general traumas as a factor moderating the effect of psychiatric disorders and emotional abuse. <italic>Conclusions.</italic> SA vulnerability in psychiatric patients is related to the joint effect of <italic>ADARB1</italic> and <italic>HTR2C</italic> variants, the existing mood disorder and the cumulative exposures to a various childhood and recent stressful experiences.</p> </abstract>