Proton T2 measurement and quantification of lactate in brain tumors by MRS at 3 Tesla in vivo. Issue 6 (7th July 2014)

• Record Type: Journal Article
• Authors: Madan, Akshay; Ganji, Sandeep K.; An, Zhongxu; Choe, Kevin S.; Pinho, Marco C.; Bachoo, Robert M.; Maher, Elizabeth M.; Choi, Changho
• Is Part Of: Magnetic resonance in medicine. Volume 73:Issue 6(2015:Jun.)
• Page Start: 2094
• Page End: 2099
• Publication Date: 2014-07-07
• Subjects: Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.25352
• Languages: English
• ISSNs: 0740-3194

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mrm25352-sec-0006" sec-type="section"> <title>Purpose</title> <p>To evaluate the T<sub>2</sub> relaxation time of lactate (Lac) in brain tumors and the correlation of the T<sub>2</sub> and concentration with tumor grades.</p> </sec> <sec id="mrm25352-sec-0007" sec-type="section"> <title>Methods</title> <p>Eight pairs of the subecho time sets of point‐resolved spectroscopy were selected between 58 and 268 ms, with numerical and phantom analyses, for Lac T<sub>2</sub> measurement. In vivo spectra were acquired from 24 subjects with gliomas (13 low grade and 11 high grade) and analyzed with LCModel using numerically‐calculated basis spectra. The metabolite T<sub>2</sub> relaxation time was obtained from monoexponential fitting of the multi‐echo time (TE) signal estimates versus TE. The metabolite concentration was estimated from the zero‐TE extrapolation of the T<sub>2</sub> fits.</p> </sec> <sec id="mrm25352-sec-0008" sec-type="section"> <title>Results</title> <p>The Lac T<sub>2</sub> was estimated to be approximately 240 ms, without a significant difference between low and high grade tumors. The Lac concentration was estimated to be 4.1 ± 3.4 and 7.0 ± 4.7 mM for low and high grades respectively, but the difference was not significant.</p> </sec> <sec id="mrm25352-sec-0009" sec-type="section"> <title>Conclusion</title> <p>The Lac T<sub>2</sub> was similar among gliomas regardless of their tumor grades. This suggests that the T<sub>2</sub> value from this study may be applicable to obtain the T<sub>2</sub> relaxation‐free estimates of Lac in a subset of brain tumors. <bold>Magn Reson Med 73:2094–2099, 2015. © 2014 Wiley Periodicals, Inc.</bold></p> </sec> </abstract>