A Systematic Review of Ketamine for Complex Regional Pain Syndrome. Issue 5 (13th January 2015)

• Record Type: Journal Article
• Authors: Connolly, Sara B.; Prager, Joshua P.; Harden, R. Norman
• Is Part Of: Pain medicine. Volume 16:Issue 5(2015)
• Page Start: 943
• Page End: 969
• Publication Date: 2015-01-13
• Subjects: Pain -- Periodicals; Pain -- Treatment -- Periodicals; Analgesics -- Periodicals; Pain -- Periodicals; Pain Management -- Periodicals; Douleur -- Périodiques; Douleur -- Traitement -- Périodiques; Analgésiques -- Périodiques; Analgésique; Soulagement de la douleur; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.047205
• DOI: 10.1111/pme.12675
• Languages: English
• ISSNs: 1526-2375

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="pme12675-sec-0001" sec-type="section"> <title>Objective</title> <p>This systematic review aims to examine the available literature and to synthesize published data concerning the treatment of Complex Regional Pain Syndrome (CRPS) with ketamine.</p> </sec> <sec id="pme12675-sec-0002" sec-type="section"> <title>Methods</title> <p>The search was conducted utilizing the databases Medline, Embase and the Cochrane Central Registry of Controlled Trials. All relevant articles were systematically reviewed.</p> </sec> <sec id="pme12675-sec-0003" sec-type="section"> <title>Results</title> <p>The search yielded 262 articles, 45 of which met the inclusion/exclusion criteria. Of those included, 6 were reviews, 5 were randomized placebo‐controlled trials, 13 were observational studies, and 21 were case reports.</p> </sec> <sec id="pme12675-sec-0004" sec-type="section"> <title>Conclusion</title> <p>There is no high quality evidence available evaluating the efficacy of ketamine for CRPS and all manuscripts examined in this review were of moderate to low quality. Therefore, we conclude there is currently only weak evidence supporting the efficacy of ketamine for CRPS, yet there is clearly a rationale for definitive study.</p> </sec> </abstract>