Noncontrast myocardial T1 mapping using cardiovascular magnetic resonance for iron overload. Issue 6 (8th August 2014)

• Record Type: Journal Article
• Authors: Sado, Daniel M.; Maestrini, Viviana; Piechnik, Stefan K.; Banypersad, Sanjay M.; White, Steven K.; Flett, Andrew S.; Robson, Matthew D.; Neubauer, Stefan; Ariti, Cono; Arai, Andrew; Kellman, Peter; Yamamura, Jin; Schoennagel, Bjoern P.; Shah, Farrukh; Davis, Bernard; Trompeter, Sara; Walker, Malcolm; Porter, John; Moon, James C.
• Is Part Of: Journal of magnetic resonance imaging. Volume 41:Issue 6(2015)
• Page Start: 1505
• Page End: 1511
• Publication Date: 2014-08-08
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24727
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24727-sec-0001" sec-type="section"> <title>Purpose</title> <p>To explore the use and reproducibility of magnetic resonance‐derived myocardial <italic>T</italic><sub>1</sub> mapping in patients with iron overload.</p> </sec> <sec id="jmri24727-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>The research received ethics committee approval and all patients provided written informed consent. This was a prospective study of 88 patients and 67 healthy volunteers. Thirty‐five patients underwent repeat scanning for reproducibility. <italic>T</italic><sub>1</sub> mapping used the shortened modified Look–Locker inversion recovery sequence (ShMOLLI) with a second, confirmatory MOLLI sequence in the reproducibility group. <italic>T</italic><sub>2</sub>* was performed using a commercially available sequence. The analysis of the <italic>T</italic><sub>2</sub>* interstudy reproducibility data was performed by two different research groups using two different methods.</p> </sec> <sec id="jmri24727-sec-0003" sec-type="section"> <title>Results</title> <p>Myocardial <italic>T</italic><sub>1</sub> was lower in patients than healthy volunteers (836 ± 138 msec vs. 968 ± 32 msec, <italic>P</italic> < 0.0001). Myocardial <italic>T</italic><sub>1</sub> correlated with <italic>T</italic><sub>2</sub>* (R = 0.79, <italic>P</italic> < 0.0001). No patient with low <italic>T</italic><sub>2</sub>* had normal <italic>T</italic><sub>1</sub>, but 32% (<italic>n</italic> = 28) of cases characterized by a normal <italic>T</italic><sub>2</sub>* had low myocardial <italic>T</italic><sub>1</sub>. Interstudy reproducibility of either <italic>T</italic><sub>1</sub> sequence was significantly better than <italic>T</italic><sub>2</sub>*, with the results suggesting that the use of <italic>T</italic><sub>1</sub> in clinical trials could decrease potential sample sizes by 7‐fold.</p> </sec> <sec id="jmri24727-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Myocardial <italic>T</italic><sub>1</sub> mapping is an alternative method for cardiac iron quantification. <italic>T</italic><sub>1</sub> mapping shows the potential for improved detection of mild iron loading. The superior reproducibility of <italic>T</italic><sub>1</sub> has potential implications for clinical trial design and therapeutic monitoring. <bold>J. Magn. Reson. Imaging 2015;41:1505–1511</bold>. © <bold>2014 Wiley Periodicals, Inc</bold>.</p> </sec> </abstract>