Associations between histologic features of nonalcoholic fatty liver disease (NAFLD) and quantitative diffusion‐weighted MRI measurements in adults. Issue 6 (25th September 2014)

• Record Type: Journal Article
• Authors: Murphy, Paul; Hooker, Jonathan; Ang, Brandon; Wolfson, Tanya; Gamst, Anthony; Bydder, Mark; Middleton, Michael; Peterson, Michael; Behling, Cynthia; Loomba, Rohit; Sirlin, Claude
• Is Part Of: Journal of magnetic resonance imaging. Volume 41:Issue 6(2015)
• Page Start: 1629
• Page End: 1638
• Publication Date: 2014-09-25
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24755
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24755-sec-0001" sec-type="section"> <title>Purpose</title> <p>To investigate in adults the associations between histologic features of nonalcoholic fatty liver disease (NAFLD) and quantitative measures derived from diffusion‐weighted imaging (DWI).</p> </sec> <sec id="jmri24755-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Eighty‐nine adults undergoing standard‐of‐care liver biopsy for NAFLD were recruited for DWI. Biopsies were scored for histologic features of NAFLD. DWI was performed using b‐values of 0, 100, and 500 s/mm<sup>2</sup>. Images were reconstructed using either conventional magnitude averaging (CMA) or a method to address bulk motion artifacts (Beta*LogNormal, BLN). The apparent diffusion coefficient (ADC) and the diffusivity (D) and perfusion fraction (F) of the intravoxel incoherent motion (IVIM) model were measured in the right hepatic lobe using both reconstructions. Associations between histologic features and DWI‐derived measures were tested statistically with several methods including multiple linear regression.</p> </sec> <sec id="jmri24755-sec-0003" sec-type="section"> <title>Results</title> <p>Using CMA and BLN reconstructions, respectively, the means (and ranges) were 1.7 (1.1–3.5) and 1.4 (1.0–3.2) × 10<sup>–3</sup>mm<sup>2</sup>/s for ADC, 1.1 (0.84–1.4) and 0.84 (0.53–1.1) × 10<sup>–3</sup>mm<sup>2</sup>/s for D, and 17 <xref ref-type="link" rid="jmri24755-bib-0005">5</xref><xref ref-type="link" rid="jmri24755-bib-0006">6</xref><xref ref-type="link" rid="jmri24755-bib-0007">7</xref><xref ref-type="link" rid="jmri24755-bib-0008">8</xref><xref ref-type="link" rid="jmri24755-bib-0009">9</xref><xref ref-type="link" rid="jmri24755-bib-0010">10</xref><xref ref-type="link" rid="jmri24755-bib-0011">11</xref><xref ref-type="link" rid="jmri24755-bib-0012">12</xref><xref ref-type="link" rid="jmri24755-bib-0013">13</xref><xref ref-type="link" rid="jmri24755-bib-0014">14</xref><xref ref-type="link" rid="jmri24755-bib-0015">15</xref><xref ref-type="link" rid="jmri24755-bib-0016">16</xref><xref ref-type="link" rid="jmri24755-bib-0017">17</xref><xref ref-type="link" rid="jmri24755-bib-0018">18</xref><xref ref-type="link" rid="jmri24755-bib-0019">19</xref><xref ref-type="link" rid="jmri24755-bib-0020">20</xref><xref ref-type="link" rid="jmri24755-bib-0021">21</xref><xref ref-type="link" rid="jmri24755-bib-0022">22</xref><xref ref-type="link" rid="jmri24755-bib-0023">23</xref><xref ref-type="link" rid="jmri24755-bib-0024">24</xref><xref ref-type="link" rid="jmri24755-bib-0025">25</xref><xref ref-type="link" rid="jmri24755-bib-0026">26</xref><xref ref-type="link" rid="jmri24755-bib-0027">27</xref><xref ref-type="link" rid="jmri24755-bib-0028">28</xref><xref ref-type="link" rid="jmri24755-bib-0029">29</xref><xref ref-type="link" rid="jmri24755-bib-0030">30</xref><xref ref-type="link" rid="jmri24755-bib-0031">31</xref><xref ref-type="link" rid="jmri24755-bib-0032">32</xref><xref ref-type="link" rid="jmri24755-bib-0033">33</xref> and 18 (2.3–35)% for F. For both reconstruction methods, D decreased with steatosis and F decreased with fibrosis (<italic>P</italic> < 0.05). ADC was not independently associated with any histologic feature.</p> </sec> <sec id="jmri24755-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Steatosis and fibrosis have significant independent effects on D and F in adults undergoing biopsy for NAFLD. <bold>J. Magn. Reson. Imaging 2015;41:1629–1638</bold>. © <bold>2014 Wiley Periodicals, Inc</bold>.</p> </sec> </abstract>