Oxygen enhanced lung MRI by simultaneous measurement of T1 and T2* during free breathing using ultrashort TE. Issue 6 (7th July 2014)

• Record Type: Journal Article
• Authors: Triphan, Simon M.F.; Breuer, Felix A.; Gensler, Daniel; Kauczor, Hans‐Ulrich; Jakob, Peter M.
• Is Part Of: Journal of magnetic resonance imaging. Volume 41:Issue 6(2015)
• Page Start: 1708
• Page End: 1714
• Publication Date: 2014-07-07
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24692
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24692-sec-0001" sec-type="section"> <title>Purpose</title> <p>To provide a robust method for the simultaneous quantification of <italic>T</italic><sub>1</sub> and <italic>T</italic><sub>2</sub>* in the human lung during free breathing. Breathing pure oxygen accelerates <italic>T</italic><sub>1</sub> and <italic>T</italic><sub>2</sub>* relaxation in the lung. While <italic>T</italic><sub>1</sub> shortening reflects an increased amount of dissolved molecular oxygen in lung tissue, <italic>T</italic><sub>2</sub>* shortening shows an increased concentration of oxygen in the alveolar gas. Therefore, both parameters reflect different aspects of the oxygen uptake and provide complementary lung functional information.</p> </sec> <sec id="jmri24692-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>A segmented inversion recovery Look–Locker multiecho sequence based on a multiecho 2D ultrashort TE (UTE) was employed for simultaneous <italic>T</italic><sub>1</sub> and <italic>T</italic><sub>2</sub>* quantification. The radial projections follow a modified golden angle ordering, allowing for respiratory self‐gating and thus the reconstruction of a series of differently <italic>T</italic><sub>1</sub> and <italic>T</italic><sub>2</sub>*‐weighted images in arbitrary breathing states. The method was evaluated in nine healthy volunteers while breathing room air and pure oxygen, with two volunteers examined at five oxygen concentrations.</p> </sec> <sec id="jmri24692-sec-0003" sec-type="section"> <title>Results</title> <p>Relative differences of Δ<italic>T</italic><sub>1</sub> between 7.9% and 12.7% and of Δ<italic>T</italic><sub>2</sub>* between 13.2% and 6.0% were found.</p> </sec> <sec id="jmri24692-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The proposed method provides inherently coregistered, quantitative <italic>T</italic><sub>1</sub> and <italic>T</italic><sub>2</sub>* maps in both expiration and inspiration from a single measurement acquired during free breathing and is thus well suited for clinical application.<bold>J. Magn. Reson. Imaging 2015;41:1708–1714.</bold> © <bold>2014 Wiley Periodicals, Inc.</bold></p> </sec> </abstract>