Platelet mitochondrial activity and pesticide exposure in early Parkinson's disease. Issue 6 (11th March 2015)

• Record Type: Journal Article
• Authors: Bronstein, Jeff M.; Paul, Kimberly; Yang, Laurice; Haas, Richard H.; Shults, Clifford W.; Le, Thuy; Ritz, Beate
• Is Part Of: Movement disorders. Volume 30:Issue 6(2015)
• Page Start: 862
• Page End: 866
• Publication Date: 2015-03-11
• Subjects: Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.26164
• Languages: English
• ISSNs: 0885-3185

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="mds26164-sec-0001" sec-type="section"> <title>Background</title> <p>Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD), but the cause of this dysfunction is unclear.</p> </sec> <sec id="mds26164-sec-0002" sec-type="section"> <title>Methods</title> <p>Platelet mitochondrial complex I and I/III (nicotinamide adenine dinucleotide cytochrome c reductase, NCCR) activities were measured in early PD patients and matched controls enrolled in a population‐based case‐control study. Ambient agricultural pesticide exposures were assessed with a geographic information system and California Pesticide Use Registry.</p> </sec> <sec id="mds26164-sec-0003" sec-type="section"> <title>Results</title> <p>In contrast to some previous reports, we found no differences in complex I and I/III activities in subjects with PD and controls. We did find that NCCR activity correlated with subjects' exposure to pesticides known to inhibit mitochondrial activity regardless of their diagnosis.</p> </sec> <sec id="mds26164-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Electron transport chain (ETC) activity is not altered in PD in this well‐characterized cohort when compared with community‐matched controls but appears to be affected by environmental toxins, such as mitochondria‐inhibiting pesticides. © 2015 International Parkinson and Movement Disorder Society</p> </sec> </abstract>