Easy To Synthesize, Robust Organo‐osmium Asymmetric Transfer Hydrogenation Catalysts. Issue 22 (8th April 2015)

• Record Type: Journal Article
• Authors: Coverdale, James P. C.; Sanchez‐Cano, Carlos; Clarkson, Guy J.; Soni, Rina; Wills, Martin; Sadler, Peter J.
• Is Part Of: Chemistry. Volume 21:Issue 22(2015)
• Page Start: 8043
• Page End: 8046
• Publication Date: 2015-04-08
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201500534
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Asymmetric transfer hydrogenation (ATH) is an important process in organic synthesis for which the Noyori‐type Ru^II catalysts [(arene)Ru(Tsdiamine)] are now well established and widely used. We now demonstrate for the first time the catalytic activity of the osmium analogues. X‐ray crystal structures of the 16‐electron Os^II catalysts are almost identical to those of Ru^II. Intriguingly the precursor complex was isolated as a dichlorido complex with a monodentate amine ligand. The Os^II catalysts are readily synthesised (within 1 h) and exhibit excellent enantioselectivity in ATH reactions of ketones.</p> </abstract>