High Blood Pressure Increases the Risk of Poor Outcome at Discharge and 12‐month Follow‐up in Patients with Symptomatic Intracranial Large Artery Stenosis and Occlusions: Subgroup analysis of the CICAS Study. (28th April 2015)

• Record Type: Journal Article
• Authors: Yu, Dan‐Dan; Pu, Yue‐Hua; Pan, Yue‐Song; Zou, Xin‐Ying; Soo, Yannie; Leung, Thomas; Liu, Li‐Ping; Wang, David Z.; Wong, Ka‐Sing; Wang, Yi‐Long; Wang, Yong‐Jun; the Chinese Intracranial Atherosclerosis (CICAS) Study Group
• Is Part Of: CNS neuroscience & therapeutics. Volume 21:Number 6(2015)
• Page Start: 530
• Page End: 535
• Publication Date: 2015-04-28
• Subjects: Neuropharmacology -- Periodicals; Central nervous system -- Diseases -- Effect of drugs on -- Periodicals; 612.8
• DOI: 10.1111/cns.12400
• Languages: English
• ISSNs: 1755-5930

Abstract

<abstract abstract-type="main" id="cns12400-abs-0001"> <title>Summary</title> <sec id="cns12400-sec-0001" sec-type="section"> <title>Aims</title> <p>The purpose of this study was to discuss the relationship between blood pressure and prognosis of patients with symptomatic intracranial arterial stenosis.</p> </sec> <sec id="cns12400-sec-0002" sec-type="section"> <title>Methods</title> <p>Data on 2426 patients with symptomatic intracranial large artery stenosis and occlusion who participated in the Chinese Intracranial Atherosclerosis (CICAS) study were analyzed. According to the JNC 7 criteria, blood pressure of all patients was classified into one of the four subgroups: normal, prehypertension, hypertension stage I, and hypertension stage II. Poor outcomes were defined as death and functional dependency (mRS 3‐5) at discharge or at 1 year.</p> </sec> <sec id="cns12400-sec-0003" sec-type="section"> <title>Results</title> <p>For patients with intracranial stenosis of 70% to 99%, the rate of poor outcome at discharge was 19.3%, 23.5%, 26.8%, and 39.8% (<italic>P</italic> = 0.001) for each blood pressure subgroup. For patients with intracranial large artery occlusion, the rates were 17.6%, 22.1%, 29.5%, and 49.8%, respectively (<italic>P</italic> < 0.0001). The rate of poor outcome at 12‐month follow‐up was 12.6%, 15.3%, 28.5%, and 27.9% (<italic>P</italic> = 0.0038) in patients with stenosis of 70% to 99% for each blood pressure subgroup and 11.6%, 21.5%, 23.9%, 35.1% (<italic>P</italic> < 0.0001) in patients with occlusion.</p> </sec> <sec id="cns12400-sec-0004" sec-type="section"> <title>Conclusions</title> <p>For patients with severe intracranial arterial stenosis or occlusion, higher hypertension stages are associated with an increased risk of poor outcome at discharge and 12‐month follow‐up.</p> </sec> </abstract>