Prognostic impact of cytogenetic abnormalities in children and adolescents with mature B‐cell non‐Hodgkin lymphoma: A report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG). Issue 7 (19th March 2015)

• Record Type: Journal Article
• Authors: Sekimizu, Masahiro; Mori, Tetsuya; Kikuchi, Akira; Mitsui, Tetsuo; Sunami, Shosuke; Kobayashi, Ryoji; Fujita, Naoto; Inada, Hiroko; Takimoto, Tetsuya; Saito, Akiko Moriya; Watanabe, Tomoyuki; Fujimoto, Junichiro; Nakazawa, Atsuko; Ohshima, Koichi; Horibe, Keizo; Tsurusawa, Masahito; for the lymphoma committee of the Japanese Pediatric Leukemia/Lymphoma Study Group
• Is Part Of: Pediatric blood & cancer. Volume 62:Issue 7(2015:Jul.)
• Page Start: 1294
• Page End: 1296
• Publication Date: 2015-03-19
• Subjects: Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.25482
• Languages: English
• ISSNs: 1545-5009

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="pbc25482-sec-0001" sec-type="section"> <p>Little information is available on cytogenetic abnormalities and their prognostic importance in childhood mature B‐cell non‐Hodgkin lymphoma (B‐NHL). We performed a review of 79 abnormal karyotypes in childhood B‐NHL treated by a uniform protocol. Del(17p) was independently associated with significantly inferior event‐free survival in Burkitt or Burkitt‐like lymphoma. The adverse prognosis of <italic>MYC</italic>/8q24 rearrangement, +7q or del(13q), was not observed, which had been suggested as risk factors in FAB/LMB96. Our results imply the possible existence of a biological difference among ethnicities and should be useful to narrow down the gene causing poor prognosis in childhood B‐NHL. Pediatr Blood Cancer 2015;62:1294–1296. © 2015 Wiley Periodicals, Inc.</p> </sec> </abstract>