Polyacrylic acid polymers hydrogels intended to topical drug delivery: preparation and characterization. (June 2015)

• Record Type: Journal Article
• Authors: Calixto, Giovana; Yoshii, Ana Carolina; Rocha e Silva, Hilris; Stringhetti Ferreira Cury, Beatriz; Chorilli, Marlus
• Is Part Of: Pharmaceutical development and technology. Volume 20:Number 4(2015)
• Page Start: 490
• Page End: 496
• Publication Date: 2015-06
• Subjects: Drug delivery systems -- Periodicals; Pharmaceutical technology -- Periodicals; Drugs -- Administration -- Research -- Periodicals; Drug Delivery Systems -- Periodicals; Pharmaceutical Preparations -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615
• DOI: 10.3109/10837450.2014.882941
• Languages: English
• ISSNs: 1083-7450

Abstract

<abstract> <title>Abstract</title> <p> <italic>Context</italic>: Bioadhesiviness of polyacrylic acid polymers make them promising hydrogels to design topical drug delivery systems, allowing a close contact with biological substrate as well as an enhanced local concentration gradient, both factors that may improve the biological performance of the drugs.</p> <p> <italic>Aim</italic>: Texture and bioadhesive properties of hydrogels were assessed by using texture analyzer and they were correlated with their rheological behavior and performance as drug delivery systems.</p> <p> <italic>Methods</italic>: Aqueous dispersions of both polymers were prepared at 0.5%, 1.0% and 1.5% w/v. Hardness, compressibility, adhesiveness, cohesiveness, bioadhesion, continuous flow, oscillatory dynamic test and <italic>in vitro</italic> drug release were evaluated.</p> <p> <italic>Results</italic>: Rheological and texture parameters were dependent on polymer concentration and C974P polymer built the strongest structures. Both 1.5% hydrogels presented high bioadhesion values. About 50% of the metronidazole (MTZ) was sustained released from hydrogels within 2 h with an initial burst release at early stage. After, the release rates were decreased and 10% of the MTZ was released in the next 10 h. The drug release process was driven by Fickian diffusion and complex mechanism for PP and C974P hydrogels, respectively.</p> <p> <italic>Conclusion</italic>: The set of results demonstrated that these hydrogels are promising to be used as topical controlled drug delivery system.</p> </abstract>