Synthesis of two new enrichable and MS-cleavable cross-linkers to define protein–protein interactions by mass spectrometry1. Issue 17 (7th May 2015)

• Record Type: Journal Article
• Authors: Burke, Anthony M.; Kandur, Wynne; Novitsky, Eric J.; Kaake, Robyn M.; Yu, Clinton; Kao, Athit; Vellucci, Danielle; Huang, Lan; Rychnovsky, Scott D.
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 17(2015)
• Page Start: 5030
• Page End: 5037
• Publication Date: 2015-05-07
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob00488h
• Languages: English
• ISSNs: 1477-0520

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgjn2npmxd" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />The cross-linking Mass Spectrometry (XL-MS) technique extracts structural information from protein complexes without requiring highly purified samples, crystallinity, or large amounts of material.</p> </abstract>