Synthesis of a new HYNIC-DAPI derivative for labelling with 99mTechnetium and its in vitro evaluation in an FRTL5 cell line. Issue 5 (13th May 2015)

• Record Type: Journal Article
• Authors: Ferl, Sandra; Wunderlich, Gerd; Smits, René; Hoepping, Alexander; Naumann, Anne; Kotzerke, Jörg
• Is Part Of: MedChemComm. Volume 6:Issue 5(2015:May)
• Page Start: 887
• Page End: 897
• Publication Date: 2015-05-13
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19
• DOI: 10.1039/c4md00574k
• Languages: English
• ISSNs: 2040-2503

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgjn2nhn58" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />A new multifunctional compound that includes the fluorescent dye 4′, 6-diamidine-2-phenylindole (DAPI) and the chelator 6-hydrazinonicotinic acid (HYNIC) was developed and radiolabelled with ^99mTc for <italic>in vitro</italic> evaluation in an FRTL5 cell line.</p> </abstract>