Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells1. Issue 4 (10th April 2015)

• Record Type: Journal Article
• Authors: Rodriguez, Veronica; Valente, Sergio; Rovida, Stefano; Rotili, Dante; Stazi, Giulia; Lucidi, Alessia; Ciossani, Giuseppe; Mattevi, Andrea; Botrugno, Oronza A.; Dessanti, Paola; Mercurio, Ciro; Vianello, Paola; Minucci, Saverio; Varasi, Mario; Mai, Antonello
• Is Part Of: MedChemComm. Volume 6:Issue 4(2015:Apr.)
• Page Start: 665
• Page End: 670
• Publication Date: 2015-04-10
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19
• DOI: 10.1039/c4md00507d
• Languages: English
• ISSNs: 2040-2503

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgjn2mvwfv" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />A new series of pyrrole/indole-containing tranylcypromine analogues is reported as potent and selective LSD1 inhibitors active in leukemia.</p> </abstract>