Diketo acids and their amino acid/dipeptidic analogues as promising scaffolds for the development of bacterial methionine aminopeptidase inhibitors. Issue 43 (14th May 2015)

• Record Type: Journal Article
• Authors: Masood, Mir Mohammad; Pillalamarri, Vijay K.; Irfan, Mohammad; Aneja, Babita; Jairajpuri, Mohamad Aman; Zafaryab, Md.; Rizvi, M. Moshahid A.; Yadava, Umesh; Addlagatta, Anthony; Abid, Mohammad
• Is Part Of: RSC advances. Volume 5:Issue 43(2015)
• Page Start: 34173
• Page End: 34183
• Publication Date: 2015-05-14
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c5ra03354c
• Languages: English
• ISSNs: 2046-2069

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgjn2g11w3" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />Diketo acids and their peptidic analogues were designed and synthesised as bacterial MetAP inhibitors. In the enzymatic assay, the representative compound <bold>5e</bold> showed excellent inhibition of bacterial MetAPs with no cytotoxicity.</p> </abstract>