Development of an efficient route toward meiogynin A-inspired dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins1. Issue 19 (21st May 2015)

• Record Type: Journal Article
• Authors: Desrat, Sandy; Remeur, Camille; Roussi, Fanny
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 19(2015)
• Page Start: 5520
• Page End: 5531
• Publication Date: 2015-05-21
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob00354g
• Languages: English
• ISSNs: 1477-0520

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgjn2bb71f" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />The synthesis, on a large scale, with very good yield and er <italic>via</italic> an efficient strategy, of a chiral 4-substituted 2-cyclohexenone intermediate, was a milestone in the synthesis of seven analogues of meiogynin A, a natural sesquiterpenoid dimer.</p> </abstract>