Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow. Issue 10 (21st May 2015)

• Record Type: Journal Article
• Authors: Esch, Mandy B.; Prot, Jean-Matthieu; Wang, Ying I.; Miller, Paula; Llamas-Vidales, Jose Ricardo; Naughton, Brian A.; Applegate, Dawn R.; Shuler, Michael L.
• Is Part Of: Lab on a chip. Volume 15:Issue 10(2015)
• Page Start: 2269
• Page End: 2277
• Publication Date: 2015-05-21
• Subjects: Miniature electronic equipment -- Periodicals; Combinatorial chemistry -- Periodicals; Biotechnology -- Periodicals; 543.0813
• DOI: 10.1039/c5lc00237k
• Languages: English
• ISSNs: 1473-0197

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgjn28k5s5" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />We have developed a low-cost liver cell culture device that creates fluidic flow over a 3D primary liver cell culture that consists of multiple liver cell types, including hepatocytes and non-parenchymal cells (fibroblasts, stellate cells, and Kupffer cells).</p> </abstract>