Cooperative catalysis of N-heterocyclic carbene and Brønsted acid for a highly enantioselective route to unprotected spiro-indoline-pyrans1. Issue 39 (14th May 2015)

• Record Type: Journal Article
• Authors: Lin, Youqiang; Yang, Limin; Deng, Yue; Zhong, Guofu
• Is Part Of: Chemical communications. Volume 51:Issue 39(2015)
• Page Start: 8330
• Page End: 8333
• Publication Date: 2015-05-14
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc02096d
• Languages: English
• ISSNs: 1359-7345

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgjn27d226" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />A chiral cooperative catalysis of NHC and Brønsted acid for a formal [4+2] reaction of unprotected isatins and enals was developed for the direct synthesis of unprotected spiro[indoline-3, 2′-pyran]-2, 6′(3′<italic>H</italic>)-diones in good to excellent yields (up to 95%) with high enantioselectivities (up to &gt;93% ee).</p> </abstract>